Acyclovir
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after dialysis
Alprazolam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Alverine
Drugs related to cardiovascular system
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Unknown
Amantadine
Antiparkinsonians
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
No additional dose, dose as in GFR <15 mL/min
Amikacin
Antibiotics/ANTIVIRAL · Aminoglycosides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
I.v. (administered after IHD): 5–12.5 mg/kg/dose 3 times weekly; according to levels; postdialysis concentrations should be drawn ≥2 and up to 4 h after hemodialysis to allow for redistribution
Amitriptyline
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, monitor ADRs, especially anticholinergic and QT interval prolonging ones, potentially due to accumulation of glucuronide metabolites
Amoxapine
Antidepressants · Tricyclic
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
No dose recommendations; avoid use, due to risk of overdosage of parent and M(+) with antidopaminergic ADRs
Amoxicillin and amoxicillin/clavulanate
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Ampicillin and ampicillin/sulbactam
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Aripiprazole
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
NDA, based on high PB of parent and M(+)
Astreonam
Antibiotics/ANTIVIRAL · Astreonam
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Atropine
Drugs related to cardiovascular system
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
No specific recommendations are available, but the need for dose adjustment is unlikely
Azithromycin
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Benzylpenicillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Bromazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
NDA, risk of overdosage should be considered during long-term use due to several M(+)
Brompheniramine
Antihistaminics
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
Dose as in normal renal function, no supplementary dose required
Buprenorphine
Opioids
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA; transdermal: dose as in normal renal function
Carbamazepine
Antiepileptics
PARTIALLY
▶
Dialyzability
Controversial (dialyzable or Not)
Recommended dose adjustment
NDA (75%–100% dose as in normal renal function + supplementary dose as in GFR <15 mL/min
Carbapenem
Antibiotics/ANTIVIRAL · Carbapenem
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
No specific dose adjustment listed.
Cefadroxil
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
1 g first dose; 500–1000 mg 3 times a week, or every 36 h, dose after IHD
Cefalexin
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Cefazolin
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Cefepime
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
1 g on day 1 followed by 0.5–1 g every 24 h, dose after IHD
Cefixime
Antibiotics/ANTIVIRAL · Cephalosporines
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Cefotaxime
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Cefoxitin
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Cefpodoxime
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
100–200 mg every 24 h, dose after IHD
Ceftazidime
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Ceftazidime/avibactam
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
0.94 g every 24 h, dose after IHD
Ceftozolane/tazobactam
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
0.75–2.25 g loading dose, followed by 1250–450 mg every 8 h, dose after IHD
Ceftriaxone
Antibiotics/ANTIVIRAL · Cephalosporines
NOT DIALYZABLE
▶
Dialyzability
Poorly dialyzable
Recommended dose adjustment
NDA
Cefuroxime
Antibiotics/ANTIVIRAL · Cephalosporines
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Chlorpheniramine
Antihistaminics
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
Dose as in normal renal function, no supplementary dose required
Chlorpromazine
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, caution should be exercised due to unknown level of M(+)
Ciprofloxacin
Antibiotics/ANTIVIRAL · Fluoroquinolones
NOT DIALYZABLE
▶
Dialyzability
Minimally dialyzable (<10%)
Recommended dose adjustment
NDA, dose after IHD
Citalopram
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, note high QT-prolonging potential vs lower potential SSRIs
Clarithromycin
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
In ESKD: for IR formulation—prolong interval for the same single dose (from twice daily to once daily), for ER formulation—50% dose
Clobazam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, effect is less predictable due to M(+)
Clomipramine
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, monitor for amitriptyline-like ADRs
Cloxacillin
Antibiotics/ANTIVIRAL · Penicillins
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Clozapine
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, based on high PB and complete metabolism with limited or no activity metabolites, but consider regulatory contraindication to use in case of severe renal disorder
Codeine
Opioids
NOT DIALYZABLE
▶
Dialyzability
Not dialyzed
Recommended dose adjustment
Avoid its use in ESKD and dialysis
Cyproheptadine
Antihistaminics
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Add 50%–100% dose supplement for IHD, consider overdosage risk
Darunavir
Antibiotics/ANTIVIRAL · Antivirals
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
Dose as in normal renal function
Diazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, effect is less predictable due to presence of several M(+)—nordazepam, oxazepam and temazepam
Dihydrocodeine
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
ND
Dimenhydrinate
Drugs related to cardiovascular system
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA + supplementary dose as in GFR <10 mL/min
Diphenhydramine
Antihistaminics
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
Dose as in normal renal function, no supplementary dose required
Doxepin
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, monitor for amitriptyline-like ADRs
Duloxetine (SNRI)
Other serotonin and norepinephrine acting
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, consider regulatory contraindication if GFR <30 mL/min
Ertapenem
Antibiotics/ANTIVIRAL · Carbapenem
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Erythromycin
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, consider limiting dose to 2 g/day due to risk of ototoxicity
Escitalopram
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
As for citalopram
Estazolam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Famciclovir
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after dialysis
Fentanyl
Opioids
NOT DIALYZABLE
▶
Dialyzability
Not dialyzed
Recommended dose adjustment
NDA
Flavoxate
Urinary antispasmodics
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Risk of overdosage due to renal excretion (57%) and presence of M(+), if dose is not adjusted, thus avoid use
Fluoxetine
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Fluvoxamine
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Foscarnet
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after dialysis
Ganciclovir
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
Oral: 500 mg 3 weekly post IHD; i.v.: NDA, dose after dialysis; for IHD, the fraction of ganciclovir removed in a single dialysis session varied from 50% to 63%
Gentamicin
Antibiotics/ANTIVIRAL · Aminoglycosides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
I.v. (administered after IHD): after reduced loading dose (e.g. 2–3 mg/kg), in case of conventional dosage regimen—1 mg/kg/dose 3 times weekly; in case of consolidated dosage regimen—2–3 mg/kg/dose 3 times weekly; according to levels; postdialysis concentrations should be drawn ≥2 and up to 4 h after hemodialysis to allow for redistribution
Hydrocodone
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Use alternative medicines
Hydromorphone
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA, metabolites may cause neuroexcitation and cognitive impairment
Hydroxyzine
Anxiolytic
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, supplement for IHD dose as in GFR <10 mL/min, consider risk of M(+), cetirizine
Imipenem/cilastatin
Antibiotics/ANTIVIRAL · Carbapenem
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
Due to neurotoxicity, consider alternative therapy; otherwise—NDA, dose after IHD
Imipramine
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, monitor for amitriptyline-like ADRs
Indinavir
Antibiotics/ANTIVIRAL · Antivirals
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
Dose as in normal renal function
Isoniazid
Antibiotics/ANTIVIRAL · Other antibiotics
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
Dose as in normal renal function, dose after dialysis
Josamycin (rovamycin)
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Unlikely to be dialyzable
Recommended dose adjustment
Consider use alternative macrolide
Levofloxacin
Antibiotics/ANTIVIRAL · Fluoroquinolones
DIALYZABLE
▶
Dialyzability
Dialyzable (up to 21% in HF)
Recommended dose adjustment
NDA, dose after IHD
Levomepromazine (methotrimeprazine)
Psycholeptics (neuroleptics)
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA, although caution should be exercised due to unknown presence or absence of activity of metabolites
Linezolid
Antibiotics/ANTIVIRAL · Other antibiotics
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after dialysis
Lithium
Other antipsychotics
DIALYZABLE
▶
Dialyzability
Dialyzable (80%)
Recommended dose adjustment
Avoid use when possible, consider risk of lithium induced kidney damage in patients with significant residual kidney function; if necessary, initiate therapy at 300 mg 3 times weekly after dialysis; gradually titrate based on clinical response, tolerability, and serum lithium levels
Lorazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, caution should be exercised for repeated i.v. formulation use due to risk of propylene glycol toxicity; monitor osmol gap closely
Lormetazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Loxapine
Psycholeptics (neuroleptics)
PARTIALLY
▶
Dialyzability
Controversial data
Recommended dose adjustment
NDA, based on high PB and complete metabolism with limited or no activity metabolites
Meperidine/pethidine
Opioids
NOT DIALYZABLE
▶
Dialyzability
Not dialyzed
Recommended dose adjustment
NDA, risk for CNS and respiratory depression due to M(+) ADRs
Meropenem
Antibiotics/ANTIVIRAL · Carbapenem
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Methadone
Opioids
NOT DIALYZABLE
▶
Dialyzability
Poorly dialyzed
Recommended dose adjustment
NDA
Metronidazole
Antibiotics/ANTIVIRAL · Other antibiotics
DIALYZABLE
▶
Dialyzability
Dialyzable in IHD, 10% removal in PD
Recommended dose adjustment
Metabolized in the liver; M(+) have long half-life in renal impairment; NDA, dose after IHD
Mianserine (tetracyclic, NE-MM)
Other serotonin and norepinephrine acting
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, consider risks stemming from variable PK and ADRs from M(+)
Midazolam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA (oral), use with caution and monitor closely for excessive sedation; consider longer dosing intervals for intermittent dosing and slower titration of continuous infusions
Mirtazapine (tetracyclic, SN-Ran)
Antidepressants · Other serotonin and norepinephrine acting
NOT DIALYZABLE
▶
Dialyzability
Unlikely to be dialyzable
Recommended dose adjustment
NDA, based on high PB and large Vd, consider risks of ADRs from M(+)
Moclobemide (RIMA—SND-RevEI)
Antidepressants · Other serotonin and norepinephrine acting
DIALYZABLE
▶
Dialyzability
Likely to be dialyzable
Recommended dose adjustment
Dose as in normal renal function
Morphine
Opioids
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, some centres avoid use slow release preparations due to M(+)
Moxifloxacin
Antibiotics/ANTIVIRAL · Fluoroquinolones
NOT DIALYZABLE
▶
Dialyzability
Poorly dialyzable
Recommended dose adjustment
NDA, dose after IHD
Nirmatrelvir
Antibiotics/ANTIVIRAL · Antivirals
NOT DIALYZABLE
▶
Dialyzability
NA
Recommended dose adjustment
Nirmatrelvir is contraindicated in case of severe renal impairment
Nitrazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Nordazepam
Benzodiazepines and similar agents
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Unknown
Norfloxacin
Antibiotics/ANTIVIRAL · Fluoroquinolones
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, dose after IHD
Nortriptyline
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
As for amitriptyline
Ofloxacin
Antibiotics/ANTIVIRAL · Fluoroquinolones
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Olanzapine
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, based on high PB, large Vd and complete metabolism to M(–)
Oxacillin
Antibiotics/ANTIVIRAL · Penicillins
NOT DIALYZABLE
▶
Dialyzability
Poorly dialyzable
Recommended dose adjustment
Due to risk of neurotoxicity, the maximum daily dose of 8 g/day may be considered, otherwise—NDA
Oxazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, risk of overdosage should be monitored
Oxcarbazepine
Antiepileptics
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA + supplementary dose as for GFR <10 mL/min
Oxybutynin
Urinary antispasmodics
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
Dose as in normal renal function, consider risk of QT prolongation and M(+) accumulation, transdermal use is less risky
Oxycodone
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA, limited accumulation of metabolites in renal failure compared with morphine
Oxymorphone
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Use alternative medicines
Paroxetine
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Perphenazine
Psycholeptics (neuroleptics)
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Unknown, caution should be exercised due to M(+)
Phenoxymethylpenicillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA
Pimozide
Psycholeptics (neuroleptics)
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
NDA, although caution should be exercised due to unknown presence or absence of M(+) and its PK
Piperacillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
2 g every 8 h + 1 g after IHD
Piperacillin and tazobactam
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
2.25 g less frequently (every 8–12 h) + 0.75 g after IHD
Polymyxins (Colistin)
Antibiotics/ANTIVIRAL · Other antibiotics
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
Increased dose: after normal loading dose (e.g. 9 MIU), 4.3 MIU per day in 2 divided doses on nondialysis days, adding 1.2 MIU after 3 h of IHD or 1.6 MIU after 4 h IHD
Prazepam
Benzodiazepines and similar agents
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, effect is less predictable due to presence of several M(+)—nordazepam and oxazepam
Promethazine
Antihistaminics
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
Some experts recommend supplementary dose
Propoxyphene
Opioids
NOT DIALYZABLE
▶
Dialyzability
Poorly dialyzed
Recommended dose adjustment
NDA
Quetiapine
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
NDA, based on relatively high PB (83%) and large Vd, although caution should be exercised due to M(+) and non-negligible renal elimination
Risperidone
Psycholeptics (neuroleptics)
NOT DIALYZABLE
▶
Dialyzability
Not significantly dialyzed
Recommended dose adjustment
Oral: use with caution, doses up to 2 mg have been tolerated, i.m. or s.c.: avoid use; risk due to extensive hepatic metabolism to M(+); both risperidone and M(+) are mainly excreted by the kidney and may increase risk of ADRs (e.g. orthostatic hypotension, QT prolongation)
Ritonavir
Antibiotics/ANTIVIRAL · Antivirals
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
Dose as in normal renal function
Roxithromycin
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Unlikely to be dialyzable
Recommended dose adjustment
Consider use alternative macrolide
Scopolamine (hyoscine)
Parasympatholytics
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Unknown
Sertraline
SSRI
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA
Spiramycin
Antibiotics/ANTIVIRAL · Macrolides
NOT DIALYZABLE
▶
Dialyzability
Unlikely to be dialyzable
Recommended dose adjustment
Consider use alternative macrolide
Sulfadiazine
Antibiotics/ANTIVIRAL · Sulfonamides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
In some countries the administration is contraindicated in case of severe renal insufficiency; if used NDA, dose after IHD
Sulfamethoxazole
Antibiotics/ANTIVIRAL · Sulfonamides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
In some countries the administration is contraindicated in case of severe renal insufficiency where repeated plasma measurements cannot be performed; if used NDA, dose after IHD
Sultamicillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Tapentadol
Opioids
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
Not recommended in ESKD
Temocillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Tenofovir
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
Avoid use; if no alternative therapy is available—NDA, dose after dialysis
Ticarcillin
Antibiotics/ANTIVIRAL · Penicillins
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Tobramycin
Antibiotics/ANTIVIRAL · Aminoglycosides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
I.v. (administered after IHD): after loading dose (e.g. 2–3 mg/kg), 1–2 mg/kg/dose 3 times weekly; according to levels; postdialysis concentrations should be drawn ≥2 and up to 4 h after hemodialysis to allow for redistribution
Tolterodine
Urinary antispasmodics
NOT DIALYZABLE
▶
Dialyzability
Unlikely
Recommended dose adjustment
NDA, consider risk of QT prolongation and M(+) accumulation, not recommended use of extended formulations
Tramadol
Opioids
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA
Trihexyphenidyl
Antiparkinsonians
PARTIALLY
▶
Dialyzability
Unknown
Recommended dose adjustment
No known effects but should be used with caution
Trimethoprim
Antibiotics/ANTIVIRAL · Sulfonamides
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after IHD
Trimipramine
Antidepressants
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable
Recommended dose adjustment
NDA, monitor for amitriptyline-like ADR
Valaciclovir
Antibiotics/ANTIVIRAL · Antivirals
DIALYZABLE
▶
Dialyzability
Yes
Recommended dose adjustment
NDA, dose after dialysis
Vancomycin
Antibiotics/ANTIVIRAL · Other antibiotics
NOT DIALYZABLE
▶
Dialyzability
Not dialyzable, but adsorbable in case of high-flux membrane
Recommended dose adjustment
Oral: NDA; i.v. (administered after IHD): after normal loading dose (e.g. 25 mg/kg), in case of low-flux membrane—7.5 mg/kg after 48 h and every 48 h; in case of high-flux membrane—10 mg/kg after 48 h and every 48 h
Venlafaxine (SNRI)
Other serotonin and norepinephrine acting
NOT DIALYZABLE
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Dialyzability
Not dialyzable?
Recommended dose adjustment
NDA, consider risks stemming from variable PK ADRs from M(+)
Zolpidem
Z-Drugs
NOT DIALYZABLE
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Dialyzability
Not dialyzable
Recommended dose adjustment
NDA: option of dosage reductions is advised by some experts due to increased protein binding
Zopiclone
Z-Drugs
PARTIALLY
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Dialyzability
Controversial data
Recommended dose adjustment
NDA, despite moderate PB (45%)